PHARMACEUTICAL COMPOSITIONS AND DOSAGE FORMS FOR BUCCAL AND SUBLINGUAL DELIVERY OF TIZANIDINE AND METHODS OF ADMINISTERING TIZANIDINE SUBLINGUALLY OR BUCALLY

摘要

Sublingual and buccal administration of the muscle spasm suppressor tizanidine increase its bioavailability by avoiding first-pass metabolism in the liver and reduce the inter-patient variation in bioavailability.