A new concept of formulation for sublingual (s.l.)vaccine delivery was developed and characterized. Thedelivery system constitutes of a mucoadhesive tabletucoadhesive based on Carbopol 974 ased 974-P NF co coated with ated the mode modelantigen ovalbumin (OVA) OVA). I . In order to obtain sublingualn (s.l.) vaccine formulations that facilitate longer contacttime of vaccine antigen with the mucosa and providebetter chemical stability properties than a solution solution-basedsystem a one one- side OVA coated tablet was developed developed.These tablets showed excellent mucoadhesion propertiesin mice. The potential as sublingual vaccine deliverysystem was examined in mice and compared to a an antigensolution solution. Although the . Elicited immune responses werehigher for s.l. Immunization with antigen solution, theresults indicate good possibilities for the futureemergen emergence of mucoadhesive s.l. Tablets for vaccinece delivery delivery.
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