A GHRH ANALOGUES OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF ABLE TO STIMULATE SECRETION OR SYNTHESIS OF GROWTH HORMONE IN A MAMMAL.

摘要

A GHRH analogue or a pharmaceutically acceptable salt thereof able to stimulate secretion or synthesis of growth hormone in a mammal. The present invention relates to growth hormone-releasing hormone (GHRH) analogues. more particularly, the invention relates to synthetic GHRH receptor in in vitro studies, in comparison with human native GHRH (1-29)NH2. The present invention also relates to a pharmaceutical composition comprising any one of said GHRH analogues and to the use of these analogues for specific stimulation of in vivo GH release as well as preparation of a drug in the treatment of GH deficiency-related conditions. The present invention also provides for a method for initiating GHRH induced biological actions in a mammal.