Heteroaryl derivatives as superior ligands for nociceptin receptor ORL-1 to be used in compositions to treat pain, cough and asthma

摘要

Disclosed is a compound of formula I wherein: R is R4- heteroaryl or pyrimidinyl; R1 is H or C1-C6 alkyl; R2and R3 are independently selected from the group consisting of -CH3, -OCH3, fluro, chloro, bromo and iodo; R4-R7 are as defined. These compounds are useful for the treatment of cough, pain, anxiety, asthma, depression and alcohol abuse.