Oxopiperidina derivatives as Melanocortin Receptor agonists and / or MC3, MC4

摘要

Referring to a oxopiperidina derived Compound of formula I, where n is 1; ra, ra and RB, Rb 'are h, cycloalkyl, among others; r1 is alkyl or cycloalkyl; R2 is heteroaryl; R3 is Halogen, alkyl, NO2, among others; R5 is alkyl or cycloalkyl Group; R4 is selected formulas (a) , (b) and (c), eventually replaced by an oxo Group,Or mono - or by an aryl or heteroaryl Group polisustituido; p is 0, 1, 2 or 3; M is 0, 1 or 2 - N; X is a link or a Link (R10) - C (r6) (R7); h R6, R7 is Halogen, among others; Halogen, alkyl, etc.; R10 is cycloalkyl, aryl, among others.Preferred compounds are: n {- (1R) - 1 - (4-chlorobenzyl) - 2 - [4 - (1H - Cyclohexyl - 4 - methyl - 1 - 1,2,4 - triazole) piperidin-1-yl] - 2-oxoethyl} - 1 - (2-phenylethyl) piperidin-4-yl Amine 4 - [4 - ((1R) - 1 - (4-chlorobenzyl) - 2 - [4 - (1H - Cyclohexyl - 4 - methyl - 1 - 1,2,4 - triazole) piperidin-1-yl] - 2-oxoethyl} amino phenol) cyclohexyl], among others. It also relates to a Pharmaceutical Composition and a preparation method.These compounds are agonists of Melanocortin MC3 and MC4 and / or are useful in the treatment of Obesity, diabetes, sexual dysfunction, among other