Include a preposition and the way to produce it

摘要

A method for producing an ingredient, characterized by: (a) dissolving epotilona in an organic solvent, such as alcohol; and (b) dissolving cyclopentanediol in an aqueous solution, optionally combined with at least another acceptable pharmaceutical ingredient, such as Manitoba and / or trombone, (c) adjust the pH of the mixture within the pH range of 5-9 using inorganic anhydrides such as hydrochloric acid, (b) mix the solvents produced in (a) and (b),Or (a) and (c),Or (E) filter (d) to obtain the original solution, (f) dry the solution to remove the solvent, resulting in solid composition. The composition obtained by the above method includes a prostate, a cyclopentanediol and at least one prostate, for example, sorbitol, and the like. Epotilona has a formula, wherein R1 is h, or1a or halogenated; R1a is h, SO2 arilo, etc.; R2 and R3 are C1-C10 tar; R4 is - (CH2) r-ch = ch - (CH2) p-r4a, etc.; R is an integer of 0-4; P is an integer of 0-3; R4A is h, C1-C10 tar, etc.; R5 is c10-c10; C16 is c10-c10 tar; C18 is c10-c10 tar. 1. Additional links or oxygen;G x = CR9 or arilo Bi or tricyclico; R9 is h, halogen, etc.; X is cr10r11; R10 and R11 are h, C1-C20 tar, etc.; a is - O - or N12; R12 is h or C1-C10 tar. This combination is useful for the treatment of growth related diseases, division and / or cell proliferation