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TARGETED CELL LYSIS OF HIV-INFECTED CELLS WITH CHIMERIC CD4 RECEPTOR-CARRYING CELLS
TARGETED CELL LYSIS OF HIV-INFECTED CELLS WITH CHIMERIC CD4 RECEPTOR-CARRYING CELLS
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机译:具有嵌合CD4受体携带细胞的HIV感染细胞的靶向细胞裂解
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摘要
Disclosed is a method of directing a cellular immune response against an HIV-infected cell in a mammal involving administering to the mammal an effective amount of therapeutic cells which express a membrane-bound, proteinaceous chimeric receptor comprising (a) an extracellular portion which includes a fragment of CD4 which is capable of specifically recognizing and binding the HIV-infected cell but which does not mediate HIV infection and (b) an intracellular portion which is capable of signalling the therapeutic cell to destroy the receptor-bound HIV-infected cell. Also disclosed are cells which express the chimeric receptors and DNA and vectors encoding the chimeric receptors.
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