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SUBSTITUTED 10-ARYL-11H-BENZO BÖFLUORENE FOR SELECTIVE EFFECTS ON OESTROGEN RECEPTORS
SUBSTITUTED 10-ARYL-11H-BENZO BÖFLUORENE FOR SELECTIVE EFFECTS ON OESTROGEN RECEPTORS
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机译:替代10-ARYL-11H-BENZOBÖFLUORENE对雌激素受体的选择性作用
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摘要
This invention provides a compound, or its possible salt, having the formula, wherein: RSUPe /SUPand 'RSUPe /SUPare OH, optionally independently etherified or esterified; Z is -CHSUB2/SUBCHSUB2/SUB- or -C(RSUP4/SUP,RSUP5/SUP)-, wherein RSUP4 /SUPand RSUP5 /SUPare independently H, (1C-2C)alkyl or form together a spiro(3C-5C)cycloalkyl; RSUP1 /SUPis H, halogen, CFSUB3/SUB, or (1C-4C)alkyl; RSUP2 /SUPand RSUP3 /SUPare independently H, halogen, -CFSUB3/SUB, -OCFSUB3/SUB, (1C-8C)alkyl, hydroxy, (1C-8C)alkyloxy, aryloxy, aryl(1C-8C)alkyl, halo(1C-8C)alkyl, -O(CHSUB2/SUB)SUBm/SUBX, wherein X is halogen or phenyl and m=2-4; -O(CHSUB2/SUB)SUBm/SUBNRSUBa/SUBRSUBb/SUB, -S(CHSUB2/SUB)SUBm/SUBNRSUBa/SUBRSUBb /SUBor -(CHSUB2/SUB)SUBm/SUBNRSUBa/SUBRSUBb/SUB, wherein m=2-4 and wherein RSUBa/SUB, RSUBb /SUBare independently (1C-8C)alkyl, (2C-8C)alkenyl, (2C-8C)alkynyl, or aryl, which alkyl, alkenyl and aryl can optionally be substituted with halogen, -CFSUB3/SUB, -OCFSUB3/SUB, -CN, -NOSUB2/SUB, -OH, (1C-8C)alkoxy, aryloxy, carboxyl, (1C-8C)alkylthio, carboxylate, (1C-8C)alkyl, aryl, aryl(1C-8C)alkyl or halo(1C-8C)alkyl; or RSUBa /SUBand RSUBb /SUBform a 3-8 membered ring structure, optionally substituted with halogen, -CFSUB3/SUB, -OCFSUB3/SUB, -CN, -NOSUB2/SUB, hydroxy, hydroxy(1C-4C)alkyl, (1C-8C)alkoxy, aryloxy, (1C-8C)alkylthio, carboxyl, carboxylate, (1C-8C)alkyl, aryl, aryl(1C-8C)alkyl, halo(1C-8C)alkyl.
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机译:本发明提供了具有下式的化合物或其可能的盐,其中:R SUPe和R SUPe是OH,任选地独立地被醚化或酯化; Z是-CH 2 SUB> CH 2 SUB>-或-C(R 4 SUP>,R 5 SUP>)-,其中R 4 SUP>和R 5 SUP>独立地为H,(1C-2C)烷基或一起形成螺(3C-5C)环烷基; R 1 SUP>是H,卤素,CF 3 SUB>或(1C-4C)烷基; R 2 SUP>和R 3 SUP>独立地为H,卤素,-CF 3 SUB>,-OCF 3 SUB>,(1C- 8C)烷基,羟基,(1C-8C)烷氧基,芳氧基,芳基(1C-8C)烷基,卤代(1C-8C)烷基,-O(CH 2 SUB>) m SUB> X,其中X是卤素或苯基且m = 2-4; -O(CH 2 SUB>) m SUB> NR a SUB> R b SUB>,-S(CH 2 SUB>) m SUB> NR a SUB> R b SUB>或-(CH 2 SUB>) m SUB> NR a SUB> R b SUB>,其中m = 2-4,并且其中R a SUB>,R b SUB>独立地是(1C -8C)烷基,(2C-8C)烯基,(2C-8C)炔基或芳基,其中烷基,烯基和芳基可以任选地被卤素,-CF 3 SUB>,-OCF 3 SUB>,-CN,-NO 2 SUB>,-OH,(1C-8C)烷氧基,芳氧基,羧基,(1C-8C)烷硫基,羧酸根,(1C-8C)烷基,芳基,芳基(1C-8C)烷基或卤代(1C-8C)烷基;或R a SUB>和R b SUB>形成3-8元环结构,可选地被卤素,-CF 3 SUB>,-OCF 取代3 SUB>,-CN,-NO 2 SUB>,羟基,羟基(1C-4C)烷基,(1C-8C)烷氧基,芳氧基,(1C-8C)烷硫基,羧基,羧酸根, (1C-8C)烷基,芳基,芳基(1C-8C)烷基,卤代(1C-8C)烷基。
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