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ANTAGONIST REPLACED IMIDAZOLS OF THE Y5 NEUROPEPTIDE Y.
ANTAGONIST REPLACED IMIDAZOLS OF THE Y5 NEUROPEPTIDE Y.
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机译:拮抗剂取代了Y5神经肽Y的咪唑。
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摘要
A compound having the structural formula: or one of its pharmaceutically acceptable salts, solvates or N-oxides, in which: X is = CH; Y represents 1 to 3 substituents independently selected from the group consisting of H, halogen, trihaloalkyl, C1-C6 alkyl, C2-C6 alkenyl, C3-C7 cycloalkyl, C1-C6 alkyl, substituted with C3-C7 cycloalkyl, -OH,, -O-C1-C6 alkyl, -SH, -S-C1-C6 alkyl, or CN. R is R4 is hydrogen or C1-C6 alkyl; R5 is C1-C6 alkyl, aryl or heteroaryl; with the proviso that R4 and R5 are not both C1-C6 alkyl, and with the proviso that when R4 is hydrogen, R5 is not C1-C6 alkyl; or, R4 and R5 together are C3-C6 alkylene and together with the nitrogen atom to which they are attached form a 4- to 7-membered ring; or, R4 and R5 together with the nitrogen to which they are attached, form a 5, 6 or 7 member ring, in which 1 or 2 ring members are independently selected
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