DERIVATIVES OF 2-CICLOHEXIL-4-FENIL-1H-IMIDAZOL AS LIGANDS OF THE Y5 NEUROPEPTIDE RECEIVER.

摘要

A compound of ** formula ** or a pharmaceutically acceptable salt thereof, wherein: R1: represents hydrogen, C1-C8 alkyl. C2-C8 alkenyl, C2-C8 alkynyl, C1-C8 alkoxy, C1-C8 alkanoyloxy, C1-C8 carbonate, C1-C8 carbamate, C1-C8 alkylthio, halogen-C1-C8 alkyl, halogen-C1-C8 alkoxy, hydroxyalkyl C1-C8, C1-C8 hydroxyalkoxy, mono or di (C1-C8) alkyl-amino, C1-C8 alkanoyl, (C1-C8) alkoxy-carbonyl, -COOH, -SO2NH2, mono or dialkylsulfonamido, -C (O ) NH2 or mono or di (C1-C8) alkylcarboxamido; R2 represents 0 to 5 ring substituents, each substituent independently selected from hydrogen, halogen, hydroxy, amino, cyano, nitro, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C1-C8 alkoxy, alkanoyloxy C1-C8, C1-C8 carbonate, C1-C8 carbamate, C1-C8 alkylthio, halo-C1-C8 alkyl, halogen-C1-C8 alkoxy, C1-C8 hydroxyalkyl, C1-C8 hydroxyalkoxy, mono or di-alkyl (C1 -C8) -amino, C1-C8 alkanoyl, (C1-C8) alkoxy -carbonyl, -COOH, -SO2NH2, mono or dialkylsulfonamido, -C (O) NH2 or mono or di-(C1-C8) alkylcarboxamido; A represents -C (O) - or -CH2-; R3 represents: (i) hydrogen; (ii) C1-C8 alkyl, optionally substituted with 1 to 8 substituents that are independently selected from halogen, hydroxyl, carbocyclic groups and heterocyclic groups, wherein each carbocyclic or heterocyclic group contains 3 to 10 ring members; or (iii) a link to R4 forming a heterocyclic group having 1 to 3 condensed or pendant rings, and each ring contains 5 to 10 members in the ring, in which each ring is optionally substituted with 1 to 5 substituents that are independently selected from halogen, cyano, nitro, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C1-C8 alkoxy, C1-C8 alkylthio, hydroxy, amino, mono or di-alkyl (C1-C8 ) -amino, halogen-C1-C8 alkyl, halogen-C1-C8 alkoxy, C1-C8 hydroxyalkyl, C1-C8 hydroxyalkoxy, C2-C8 alkanoyl, (C1-C8) alkoxycarbonyl, -COOH, -SO2NH2, mono or dialkylsulfonamido, -C (O) NH2 or mono odi-(C1-C8) alkylcarboxamido; X represents a bond, -S (O) 2-, -C (O) - or -NHC (O) -