NON CENTROSIMETRIC ANALOGS OF PHTALOCIANINE REPLACED BY METALS, ITS PREPARATION AND ITS USE IN PHOTODYNAMIC THERAPY AND IN VIVO DIAGNOSIS.

摘要

Non-centrimetric substituted metal phthalocyanines selected from the group consisting of 2 - [(4-sulphonate) phenoxy] - 9, 10, 16, 17, 23, 24-hexa [3- (dimethylamino) phenoxy] zinc (II ) phthalocyanine; hexayodides of 2 - [(4- sulfonate) phenoxy] -9, 10, 16, 17, 23, 24-hexa [3- (trimethylammonium) phenoxy] zinc (II) phthalocyanines, and phthalocyanine of ** formula ** where: n is 1, 2 or 4; M is chosen from the group consisting of Zn, Si (OR7) 2 and AlOR7 where R7 is chosen from the group consisting of H, C1-15 alkyl; R is selected from the group consisting of: -COOH, -SH, -OH, -NH2, -CO-CH2-Br, - SO2Cl, maleimide, hydrazide, phenol, imidate, biotin, possibly linked to phthalocyanine nuclei by an aliphatic or aromatic part that acts as a separator and R1 is represented by the group (X) pR2, where: X is chosen from the group consisting of O, S, -NR5 and -CH2- and R2.