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Metal-substituted non-centrosymmetric phthalocyanine analogs, their preparation and use in photodynamic therapy and in vivo diagnostics
Metal-substituted non-centrosymmetric phthalocyanine analogs, their preparation and use in photodynamic therapy and in vivo diagnostics
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机译:金属取代的非中心对称酞菁类似物,其制备及其在光动力疗法和体内诊断中的应用
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摘要
Phthalocyanine analogues having an active group able to link the phthalocyanine t carriers molecules and phthalocyanine to carriers molecules and phthalocyanine analogues as phthalocyanine-carrier conjugates showing enhanced photodynamic properties, red shifted absorption characteristic, all useful for photodynamic therapy, are described. Photosensitizers themselves or the photosensitizers-carriers conjugates are useful compounds either for treatment of various infectious diseases, the in vivo eradication of micro-organisms as well as diseases characterized by cellular hyperproliferation, in particular tumours psoriasis, actinic keratosis, atheromas, endoarterial hyperplasia and prostate hyperplasia. The above compounds can be also useful for blood and blood derivatives sterilization and in vivo/vitro diagnostics.
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