ANTAGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS AND THEIR USE FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES.

摘要

A compound having the structure in which X1 and X2 are independently CH or N, X3 is N or CE A, B, D, and E are independently selected from the group consisting of H, OMe, F, and CF3, or B and D together are ¿O- (CH2) -O- or O- (CH2) 2-O-, with the proviso that at least one of A, B, D, and E is different from H, R is selected from the group consisting of: C4-C6 alkyl, in which K is H or Me, G1 is H, Me, or phenyl, G2, K, L, and M are independently H or Me, N is 0, 1 or 2, and X4 and X5 are independently N or CH, or a pharmaceutically acceptable salt thereof.