METHOD FOR PREPARING THERAPEUTIC OPHTHALMIC ARTICLES USING COMPRESSED FLUIDS

摘要

The present invention describes a method for theimpregnation of a drug or a drug composition intoophthalmic articles, in order to prepare drug sustainedrelease systems mainly for the treatment of glaucoma andother eye diseases. Ophthalmic articles can be for examplecontact lenses.The drug or drug composition is dissolved in acompressed fluid, or mixture of compressed fluids, in aliquid, sub-critical liquid, gaseous or supercriticalstate. Co-solvents can be added to increase drug solubilityin the compressed fluids. The mixture is subsequentlycontacted with the ophthalmic article. This process can bedone in a single step or in a double step manner. Theimpregnation can be carried out in finished or semi-finished ophthalmic articles.