COMPOSITIONS AND METHODS FOR DETECTING OPEN CHROMATIN AND FOR GENOME-WIDE CHROMATIN STATE PROFILING

摘要

Methods and compositions are provided for detecting open chromatin in genomic DNA, including oligonucleotide arrays useful for detecting open chromatin and generating chromatin state profiles for biological samples. The invention further concerns the use of such arrays in diagnostic and prognostic methods, as well as in methods of monitoring treatment and evaluating the response of cells and patients to candidate or established therapeutic agents. The invention also concerns the use of such arrays for the provision of pharmacogenomic data useful in methods of tailoring treatment to individuals. The invention additionally concerns the use of such arrays for the identification of chromatin state profiles representative of cell types or cell states, which may be used to evidence cell types or cell states.