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HIGHLY SELECTIVE BUTYRYLCHOLINESTERASE INHIBITORS FOR THE TREATMENT AND DIAGNOSIS OF ALZHEIMER'S DISEASE AND DEMENTIAS

机译：用于治疗和诊断老年痴呆症和老年痴呆症的高度选择性的丁酰胆碱酯酶抑制剂

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摘要

A method for treating cognitive impairments associated with aging or Alzheimer's disease which comprises treating a patient at risk for having the cognitive impairment with an effective amount of a highly selective butyrylcholinesterase inhibitor which is N8-benzylnorcymserine, N1-phenethylnorcymserine, N1, N8-bisnorcymserine, N1-N8-bisbenzylnorphysostigmine, N1, N8-bisbenzylnorphenserine, N1, N8-bisbenzylnorcymserine, or pharmaceutical acceptable salts thereof.

机译：一种用于治疗与衰老或阿尔茨海默氏病相关的认知障碍的方法，该方法包括用有效量的高选择性丁酰胆碱酯酶抑制剂（N 8-苄基冰藓碱，N 1-苯乙基冰藓碱， N 1，N 8-双正西半胱氨酸，N 1 -N 8-双苄基正卟啉，N 1，N 8-双苄基去甲丝氨酸，N 1，N 8-双苄基正西半胱氨酸或药物其可接受的盐。

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公开/公告号EP0949920B1

专利类型
公开/公告日2005-12-07

原文格式PDF
申请/专利权人 AXONYX;NATIONAL INSTITUTES OF HEALTH;
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申请/专利号EP19980933230
发明设计人 GREIG NIGEL H.;YU QIAN-SHENG;BROSSI ARNOLD;SONCRANT TIMOTHY T.;HAUSMAN MARVIN;
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申请日1998-07-09
分类号A61K31/40;C07D209/58;C07D491/04;C07D491/048;A61K31/00;A61K51/04;A61P25/28;
国家 EP
入库时间 2022-08-21 21:33:24

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