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Pursuing the Complexity of Alzheimer’s Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N-Methyl-d-Aspartate Receptor Antagonists

机译：追求阿尔茨海默病的复杂性：发现氟化丁烯-9-胺作为选择性丁二醇酸酶抑制剂和N-甲基-D-天冬氨酸受体拮抗剂

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Jan Konecny; Anna Misiachna; Martina Hrabinova; Lenka Pulkrabkova; Marketa Benkova; Lukas Prchal; Tomas Kucera; Tereza Kobrlova; Vladimir Finger; Marharyta Kolcheva; Stepan Kortus; Daniel Jun; Marian Valko; Martin Horak; Ondrej Soukup; Jan Korabecny;
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1. Conjugates of γ-Carbolines and Phenothiazine as new selective inhibitors of butyrylcholinesterase and blockers of NMDA receptors for Alzheimer Disease [J] . Galina F. Makhaeva, Sofya V. Lushchekina, Natalia P. Boltneva, Scientific reports. . 2015,第期

机译：γ-蛋白和吩噻嗪的缀合物作为丁酰胆碱酯酶的新选择性抑制剂，并对阿尔茨海默病的NMDA受体阻断
2. Pharmacology of acetylcholinesterase inhibitors and N-methyl-D-aspartate receptors for combination therapy in the treatment of Alzheimer's disease. [J] . Geerts H, Grossberg GT The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology . 2006,第7Suppla期

机译：乙酰胆碱酯酶抑制剂和N-甲基-D-天冬氨酸受体联合治疗阿尔茨海默氏病的药理作用。
3. Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease [J] . Purgatorio Rosa, de Candia Modesto, Catto Marco, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2019,第期

机译：研究1,2,3,4,5,6-六羟基哌嗪[4,3-B]吲哚作为丁酰胆碱酯酶选择性抑制剂的支架，具有额外的Alzheimer疾病的神经保护活性
4. Virtual screening, ADMET profiling, molecular docking and dynamics approaches to search for potent selective natural molecule based inhibitors against metallothionein-III to study Alzheimer's disease [C] . Roy Sandip, Kumar Ajit, Provaznik Ivo IEEE International Conference on Bioinformatics and Biomedicine . 2014

机译：虚拟筛选，ADMET分析，分子对接和动力学方法以寻找有效的基于选择性天然分子的金属硫蛋白-III抑制剂来研究阿尔茨海默氏病
5. Synthesis of Bivalent Organothiophosphate Inhibitors and Their Inhibition of Butyrylcholinesterase: Studies towards a Potential Treatment of Cognitive Loss Associated with Alzheimer's Disease [D] . Tahira, Ambreen. 2017

机译：二价有机硫代磷酸酯抑制剂的合成及其对丁酰胆碱酯酶的抑制：潜在治疗与阿尔茨海默氏病相关的认知丧失的研究
6. Pursuing the Complexity of Alzheimer’s Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and [O] . Jan Konecny, Anna Misiachna, Martina Hrabinova, 2021

机译：追求阿尔茨海默病的复杂性：发现氟丁烯-9-胺作为选择性丁酰胆碱酯酶抑制剂和
7. Comparative Effects of LY3020371, a Potent and Selective Metabotropic Glutamate (mGlu) 2/3 Receptor Antagonist, and Ketamine, a Noncompetitive N-Methyl-d-Aspartate Receptor Antagonist in Rodents: Evidence Supporting the Use of mGlu2/3 Antagonists, for the Treatment of Depression. [O] . J.M. Witkin, S.N. Mitchell, K.A. Wafford, 2017

机译：Ly3020371，效率和选择性代谢谷氨酸（Mglu）2/3受体拮抗剂和氯胺酮，在啮齿动物的非竞争性N-甲基-D-天冬氨酸受体拮抗剂中的比较效果：证据支持使用MGLU2 / 3拮抗剂，用于治疗抑郁症。

Pursuing the Complexity of Alzheimer’s Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N-Methyl-d-Aspartate Receptor Antagonists

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