RNA DEPENDENT RNA POLYMERASES/PRIMASES FROM CORONAVIRUS AND THEIR USE IN MOLECULAR BIOLOGY AND DRUG SCREENING

摘要

The present invention concerns a RNA dependent RNA polymerase/primase the amino acid sequence of which presents at least 60% similarity with the following sequence AIASEFSSLPSYAAYATAQEAYEQAVANGDSE VVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINMDNSPNL AWPLIVTALRANSAVKLQ (SEQ ID NO. 1 in the sequence listing in appendix) and fragments thereof. The present invention also concerns its use as a biotech reagent and/or in a method for screening biologically active compound which can be used as antiviral agent.