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TREATMENT FOR METHAMPHETAMINE ADDICTION AND REDUCTION OF METHAMPHETAMINE USE USING SEROTONIN ANTAGONISTS
TREATMENT FOR METHAMPHETAMINE ADDICTION AND REDUCTION OF METHAMPHETAMINE USE USING SEROTONIN ANTAGONISTS
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机译:血清素拮抗剂治疗甲氧麻黄碱成瘾和减少甲氧麻黄碱的使用
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摘要
Methods for screening specific biological endpoints that can be utilized to identify potential therapeutic agents for METH addiction. In one aspect of the invention, the methods involve reversal of behavioral sensitization and/or conditioned place preference in an animal previously treated with METH in the presence of a known amount of a 5-HT2A/2C antagonist or a selective 5-HT2C antagonist, and reversal of the electrophysiological endpoints in a METH-treated animal in the presence of a known amount of the 5-HT2A/2C antagonist or the selective 5-HT2C antagonist. Therapeutic treatment methods for reversing the set of biological endpoints that change in the METH drug addict using mirtazapine, SDZ SER 082, and related serotonin antagonists are also provided. The methods of the invention may be utilized in the identification of potential new therapies for multiple drugs of abuse.
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机译:筛选可用于识别潜在的METH成瘾治疗剂的特定生物学终点的方法。在本发明的一方面,该方法涉及在已知量的5-HT 2A / 2C拮抗剂或选择性5-HT 2C拮抗剂存在下,先前用METH治疗的动物中行为敏感性和/或条件位置偏好的逆转。在已知量的5-HT2A / 2C拮抗剂或选择性5-HT2C拮抗剂存在下,在METH处理的动物体内,电生理终点的变化和逆转。还提供了使用米氮平,SDZ SER 082和相关的5-羟色胺拮抗剂来逆转METH药物成瘾者发生变化的一组生物学终点的治疗方法。本发明的方法可以用于鉴定多种滥用药物的潜在新疗法。
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