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PROPOFOL FORMULATION WITH ENHANCED MICROBIAL INHIBITION
PROPOFOL FORMULATION WITH ENHANCED MICROBIAL INHIBITION
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机译:具有增强微生物抑制作用的丙泊酚制剂
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摘要
A sterile, stable pharmaceutical formulations of oil-in-water emulsions of Propofol containing no preservative are provided that comprise optimal amounts of egg lecithin and soybean oil, with a suitable pH range to prevent significant growth of microorganisms for at least 24 hours after adventitious, extrinsic contamination. The lower pH in the formulation has shown the most antimicrobial activity. The reduced amount of fat in the formulation also allows chronic sedation over extended periods of time with a reduced chance of fat overload in the blood.
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