ANIMAL MODEL FOR STUDYING SUBSTANCES WITH CARDIOTHERAPEUTIC AND ANTI-HYPERTENSIVE ACTIVITY

摘要

An experimental model of mouse generated by knocking-in an encoding H-ras sequence into K-ras locus is disclosed. In these mice, both copies of the K-ras gene contain the encoding region of H-ras under the control of the regulatory regions of the K-ras gene; methods for assaying cardiotherapeutic or anti-hypertensive substances.