Whole Animal Model for In vivo Studies of the Effects of Environmental (Thermal) Stress and Vasoactive Substances on Peripheral Blood Flow.

摘要

A whole animal model for in vivo studies of the effects of pharmacological vasoactive substances and environmental stress on peripheral blood flow is described. The rat was selected as the basis of the model because its long conical tail lends itself to both venous occlusion plethysmographic measurement of total blood flow and laser Doppler flowmetry for measurement of cutaneous microvascular flow. These two non-invasive measures of blood flow at different levels in the vascular tree provide insight about the location at which substances affect the vasculature. Furthermore, the ability to compare blood flow in the foot pad and tail, i.e., two distinct peripheral vascular beds, allows for assessment of the homogeneity of responses.... Laser doppler flowmetry, Venous occlusion plethysmography, Peripheral blood flow, Norepinephrine, Rat.