Methods of Autophagy Induction in Mammalian Cells. This invention relates to the induction of autophagy in cells through inhibition of inositol monophosphatase (IMPase) and reduction in the level of free inositol (IP3). This may, for example, be useful in the treatment of a range of conditions, including neurodegenerative disorders and bacterial infections such as tuberculosis. Therapeutic compounds, uses and methods of treatment are provided, along with methods of screening for autophagy inducers.
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