INHIBITORS OF BACTERIAL TYPE III PROTEIN SECRETION SYSTEMS

摘要

In accordance with the present invention, compounds having formula (I), where the variables are as identified in the claims, that inhibit Type III protein secretion have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of Type III protein secretion and/or in the treatment and prevention of bacterial infections, particular Gram-negative bacterial infections, are provided. In another aspect of the invention, methods are provided for the inhibition of Type III protein secretion and/or the treatment and prevention of bacterial infections, particular Gram-negative bacterial infections using the compounds of the invention.