IDENTIFICATION OF AN EVOLUTIONARILY CONSERVED PATHWAY MEDIATING TRANSREPRESSION OF INFLAMMATORY RESPONSE GENES BY NUCLEAR RECEPTORS

摘要

The present invention relates to a method of screening for a compound that regulate SUMOylation of the nuclear receptor proteins comprising contacting the compound of interest to the nuclear receptor protein, and detecting SUMOylation of the nuclear receptor protein, thereby screening for a compound that regulates SUMOylation.