ADMINISTRATION OF MACROPHAGE TARGETED FORMULATIONS OF COMPOUNDS WHICH MODULATE CHOLESTEROL-METABOLIZING ENZYMES FOR TREATMENT OF ATHEROSCLEROSIS

摘要

Macrophage targeting formulations of compounds for treating atherosclerosis, in particular compounds which modulate cholesterol -metabolizing enzymes including, but not limited to acyl CoA: cholesterol acyl transferase (ACAT) inhibitors, cholesterol ester hydrolase (CEH) enhancers and combinations thereof, are provided. Methods for short term administration of these macrophage targeting formulations to promote regression and/or inhibit formation of atherosclerotic plaque, as well as to treat atherosclerosis, inflammation, coronary heart disease and cardiovascular disease are also provided.