Administration of macrophage targeted formulations of compounds which modulate cholesterol-metabolizing enzymes for treatment of atherosclerosis

摘要

Macrophage targeting formulations of compounds for treating atherosclerosis, in particular compounds which modulate cholesterol-metabolizing enzymes including, but not limited to acyl CoA:cholesterol acyl transferase (ACAT) inhibitors, cholesterol ester hydrolase (CEH) enhancers and combinations thereof, are provided. Methods for short term administration of these macrophage targeting formulations to promote regression and/or inhibit formation of atherosclerotic plaque, as well as to treat atherosclerosis, inflammation, coronary heart disease and cardiovascular disease are also provided.