TARGETED CHOLERA TOXIN FOR TREATMENT OF PERSISTENT OR CHONIC PAIN

摘要

Disclosed herein is a compound engineered by conjugating a cholera toxin (or subunit thereof), to a targeting molecule that assists in targeting the cholera toxin to a specific g-protein coupled receptor on neurons. Targeting molecules disclosed herein may include but are not limited to, substance P, an opioid, and CGRP, or any peptide for which there is a g-protein coupled receptor. Specifically exemplified is the engineering of a compound involving conjugating Substance P to a cholera toxin, wherein the compound suppresses pain in a subject while minimizing cell death of neurons.