Method and instrument for low temperature microwave assisted organic chemical synthesis

摘要

An instrument (10) and associated method are disclosed for performing microwave assisted organic chemical synthesis at low temperatures. The instrument (10) includes a reaction vessel (20) formed of a microwave transparent material that defmes an interior reaction chamber (17) for carrying out microwave assisted reactions in the chamber, a cooling jacket (22) immediately surrounding the reaction vessel for cooling the vessel and the vessel (20) contents during the application of microwave energy (25) to contents in the vessel when a microwave transparent media used as a fluid coolant is present in the jacket. The instrument includes means (18) for supplying a microwave transparent fluid coolant to the cooling jacket and means (19) for venting the fluid coolant from the cooling jacket (22), a fluid coolant reservoir (59) in communication with the cooling jacket, and a pump (61) in communication with the reservoir (59) and the cooling jacket (22) for circulating fluid coolant from the fluid coolant reservoir through the cooling jacket and around the reaction vessel.