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ULTRASENSITIVE DETECTION OF PRIONS BY AUTOMATED PROTEIN MISFOLDING CYCLIC AMPLIFICATION
ULTRASENSITIVE DETECTION OF PRIONS BY AUTOMATED PROTEIN MISFOLDING CYCLIC AMPLIFICATION
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机译:蛋白质错配循环扩增技术超灵敏检测子
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摘要
A highly sensitive method is provided for the detection of prions in a sample. These methods may be used to diagnose prion mediated transmissible spongiform encephalopathies such as bovine spongiform encephalopathy, Creutzfeldt- Jakob disease, scrapie, or chronic wasting disease. In particular a method for serial automated cyclic amplification of prion is disclosed. The method is both rapid and highly sensitive making it ideal for high throughput testing.
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