Methods for evaluating pathologies or therapeutics in a rat carotid artery

摘要

A methodology for evaluating the efficacy of locally applied antiproliferatives and/or other therapeutic agents on neointimal hyperplasia, as well as immunohistochemical and vascular cell cycle changes, in balloon-injured rat carotid arteries may be utilized for determining the efficacy of treatments in humans.;In one aspect, a method for evaluating pathologies in a rat carotid artery is described. The method comprises: endovascularly creating an injury in at least one location within the carotid artery of a rat; and evaluating the pathologies associated with the injury.