MICROFLUIDIC FLUORESCENE DETECTION SYSTEM FOR HIGH-THROUGHPUT SCREENING AGAINST RNA TARGETS

摘要

The present invention relates to an RNA-binding drugs search method using the microfluidic fluorescence detection system control, and more particularly it is controlled by using a microfluidic chip (chip) A method for screening a compound that specifically binding to the RNA target molecule as well, the fluorescent probe (probe) that binds to the RNA target molecule with a fluorescence probe molecule is attached inducing compound and a competitive reaction with a fluorescence probe molecule to a method for efficiently screening the RNA-specific binding compound. When using the present invention takes the target molecule, the probe molecule and a compound of 1/10 or less compared with the conventional method is economical, because it does not use a radioactive isotope, is also environmentally safe, by conventional electron assimilation system analysis time is shorter than the method of, we can reduce the error may be useful in drug navigation field.