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USE OF DERIVATIVES OF 2,4-DIHYDRO-1,2,4TRIAZOLE-3-THIONE AS INHIBITORS OF THE ENZYME MYELOPEROXIDASE(MPO)
USE OF DERIVATIVES OF 2,4-DIHYDRO-1,2,4TRIAZOLE-3-THIONE AS INHIBITORS OF THE ENZYME MYELOPEROXIDASE(MPO)
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机译:2,4-二氢-[1,2,4]三唑-3-硫酮衍生物作为酶髓过氧化物酶(MPO)抑制剂的用途
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摘要
There is disclosed the use of a compound of formula (I) wherein X, Y, W and Q are as defined in the specification, and pharmaceutically acceptable salts thereof, in the manufacture of a medicament, for the treatment or prophylaxis of diseases or conditions in which inhibition of the enzyme myeloperoxidase (MPO) is beneficial. Certain novel compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed, together with processes for their preparation. The compounds of formulae (I) are MPO inhibitors and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders.
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