Myeloperoxidase (MPO) Gene Polymorphism confers Cirrhotic Patients with Hepatopulmonary Syndrome

摘要

In this study,we investigated the-463G/A promoter polymorphism of the MPO gene,in an attempt to explore the role of MPO in the pathogenesis of HPS caused by cirrhosis.The polymorphism of the MPO gene means the individual genotypes have different initial mRNA transcription activities and different expression levels,which further influences the activities of enzymes and results in the variation in disease susceptibility.This paper addresses gene polymorphisms play a key role in the development of HPS in cirrhotic patients.