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Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans

机译：硫酸衍生物PF-06282999的药代动力学和配置，一种口服生物，肌释放酶酶的口服生物可利用者，肌肉氧化酶，血液和人类

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J. Q. Dong; M. V. Varma; A. Wolford; T. Ryder; L. Di; B. Feng; S. G. Terra; K. Sagawa; A. S. Kalgutkar;
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1. Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans [J] . Dong Jennifer Q., Varma Manthena V., Wolford Angela, Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2016,第2期

机译：硫氧尿嘧啶衍生物PF-06282999（一种在动物和人体内口服生物利用，不可逆的髓过氧化物酶的灭活剂）的药代动力学和处置
2. Induction of human cytochrome P450 3A4 by the irreversible myeloperoxidase inactivator PF-06282999 is mediated by the pregnane X receptor [J] . Moscovitz, J.E., Lin, Xenobiotica: the fate of foreign compounds in biological systems . 2018,第1a12期

机译：通过不可逆髓过氧化物酶灭失剂PF-06282999诱导人细胞色素P450 3A4的诱导由妊娠X受体介导
3. Examination of the Human Cytochrome P4503A4 Induction Potential of PF-06282999, an Irreversible Myeloperoxidase Inactivator: Integration of Preclinical, In Silico, and Biomarker Methodologies in the Prediction of the Clinical Outcome [J] . Dong Jennifer Q., Gosset James R., Fahmi Odette A., Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2017,第5期

机译：PF-06282999的人细胞色素P4503A4诱导潜力，一种不可逆转的髓氧化酶灭失剂：临床前，硅和生物标志物方法的临床结果中的一体化
4. CNX-774, an Irreversible, Selective and Orally Bioavailable Inhibitor of Bruton's Tyrosine Kinase: In Vitro ADME, Selectivity, and Pharmacokinetic Properties [C] . Prasoon Chaturvedi, Matthew Labenski, Erica Evans, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：CNX-774，Bruton的酪氨酸激酶的不可逆转，选择性和口服生物可利用的抑制剂：体外Adme，选择性和药代动力学性能
5. Integration of preclinical and clinical data with pharmacokinetic modeling and simulations to characterize the disposition of orally-active antiparasitic prodrugs and metabolites: Prediction of the dose-exposure relationship in humans. [D] . Yan, Zhixia. 2011

机译：临床前和临床数据与药代动力学建模和模拟的集成，以表征口服活性抗寄生虫前药和代谢物的分布：预测人类的剂量-暴露关系。
6. Pharmacokinetics oral bioavailability and metabolic disposition in rats of (-)-cis-5-fluoro-1-2-(hydroxymethyl)-13-oxathiolan-5-yl cytosine a nucleoside analog active against human immunodeficiency virus and hepatitis B virus. [O] . L W Frick, L St John, L C Taylor, 1993

机译：（-）-顺-5-氟-1- 2-（羟甲基）-13-氧硫杂环戊烷-5-基胞嘧啶（对人免疫缺陷病毒有活性的核苷类似物）在大鼠体内的药代动力学口服生物利用度和代谢处置和乙肝病毒。
7. Pharmacokinetics, oral bioavailability, and metabolic disposition in rats of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analog active against human immunodeficiency virus and hepatitis B virus. [O] . Frick, L W, St John, L, Taylor, L C, 1993

机译：（-）-顺-5-氟-1- [2-（羟甲基）-1,3-氧硫杂环戊烷-5-基]胞嘧啶（对人免疫缺陷病毒有活性的核苷类似物）在大鼠体内的药代动力学，口服生物利用度和代谢处置和乙肝病毒。

Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans

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