SMALL INTERFERING RNA SPECIFIC FOR S-ADENOSYLMETHIONINE DECARBOXYLASE MRNA AND THERAPEUTIC AGENT FOR MALIGNANCY COMPRISING THE SAME

摘要

The present invention relates to a cancer therapeutic agent containing a specific small interfering RNA (siRNA), and the effective ingredient to him S- adenosyl methionine decarboxylase mRNA. siRNA of the invention is complementary to the S- adenosyl-methionine decarboxylase (S-adenosylmethionine decarboxylase) sense sequence of 17 to 29 Merced selected from the base sequence of mRNA, of 4 to 8 Murray loop sequence and the sense sequence It is composed of the antisense sequence to bind. The present invention of S- adenosyl-malignant tumor therapeutic agents, including a methionine decarboxylase mRNA specific for the effective siRNA and the siRNA is a component necessary for the various repairs when, DNA damage when transduced to malignant tumor cells in particular premyelocytic leukemia cells inhibiting the expression of a gene of S- adenosyl methionine decarboxylase relating to the synthesis of polyamines related to expression of the gene by inhibiting the growth of premyelocytic leukemia cells, increasing apoptosis, to gamma radiation and DNA damaging factor by damage caused by at inhibiting the expression of the repair enzyme maximize cell death (apoptosis), when used in combination with chemotherapy or radiation therapy, it will be very effectively used in cancer therapy. ; siRNA, S- adenosyl methionine decarboxylase, SAMDC, malignancy, a therapeutic agent