THE HALICYLINDRAMIDE EXTRACTED HALICHONDRIA SP., AND A MEDICINE CONTAINING THE SAME

摘要

The invention sponges Harley mitochondrial ( Halichondria sp.) Extracted from The Harley appeared in the drama Droid (Halicylindramide), published his Harley drama Eid A, C, and Harley Harley appeared drama Eid Eid appeared drama of human low-density lipoprotein F is (LDL; low density lipoprotein) cholesterol levels and lower the effective, high-density fat protein (HDL; high density lipoprotein) Ipanema small Id orphan nuclear receptors are known to increase the; relates to a hyperlipemia therapeutic agent comprising as an active ingredient of this antagonism and (FXR Farnesoid X Receptor). By freeze-drying the sponge to remove water completely, and Harley mitochondrial order to extract the substance, extracted with dichloromethane and methanol, the solvent was evaporated under reduced pressure. The distribution of the residue in methanol and n- hexane extraction to thereby remove the solvent under reduced pressure from the resulting methanol layer. The residue was re-partitioned between ethyl acetate and water extraction, where the resulting aqueous phase is extracted with n- butanol distribution. After removal of the solvent n- butanol layer thus obtained under reduced pressure, the residue was purified by column chromatography with a resin of the two half-time reverse phase - can be obtained the products was purified by preparative HPLC ; The The Harley appeared drama drama Eid Eid, A and C, and the new Harley-cylinder Harley-cylinder marine natural product upgrade F is separated into how the drama has an excellent inhibitory activity on Ipanema small upgrade orphan nuclear receptors involved in cholesterol metabolism, exhibit low cytotoxicity .