- / Recombinant Adeno-associated Virus Comprising VEGFR Truncated Soluble cDNA and Gene Therapeutic Agent Specific to Large Intestine Cancer Bladder Cancer and/or Lung Cancer Comprising the Same

摘要

The present invention relates to gene therapy using truncated soluble cDNA of VEGF receptor protein (VEGFR) and adeno-associated virus (AAV) system, and more particularly, rAAV vector containing truncated soluble cDNA of VEGFR, and the vector and VEGF. Colorectal cancer, bladder cancer and / or lung cancer-specific gene therapy comprising rAAV vectors containing anti-sense cDNA.;Gene therapeutic agents according to the present invention can be effectively used to treat cancer at the genetic level by inhibiting the expression and function of VEGF involved in angiogenesis essential for tumor growth and metastasis, thereby reducing tumor growth.;Angiogenesis, gene therapy, VEGF, VEGF receptor, adeno-associated virus