RECOMBINANT ADENO-ASSOCIATED VIRUS COMPRISING ANTISENSE CDNAS OF VEGF-A, VEGF-B AND VEGF-C AND GENE THERAPEUTIC AGENT SPECIFIC TO LARGE INTESTINE CANCER, BLADDER CANCER AND/OR LUNG CANCER COMPRISING THE SAME

摘要

The present invention relates to a gene therapeutic agent using antisense cDNAs of VEGF-A, VEGF-B and VEGF-C and adeno-associated virus(AW) system, and more particularly, relates to a gene therapeutic agent specific to large intestine cancer, bladder cancer and/or lung cancer, comprising a rAAV vector containing antisense cDNAs of VEGF-A, VEGF-B and VEGF-C, and said rAAV vector. The gene therapeutic agent according to the present invention reduces the growth of tumors by efficiently inhibiting the expression of VEGF involved in angiogenesis necessary for the proliferation and metastasis of tumors. Thus, the inventive gene therapeutic agent can be effectively used to treat cancer at a gene level.