High Drug Load Immediate and Modified Release Oral Dosage Formulations and Processes for their Manufacture

摘要

This invention relates to high drug load granulation of (E)- alpha - [2-n-butyl-1- [(4-carboxyphenyl) methyl]-1H- imidazol-5-yl] methylene-2- thiophenepropionic acid in the anhydrous form, a process for its production, compositions containing the compound and methods of using the compound to block angiotensin II receptors and to treat hypertension, congestive heart failure and renal failure.