HIGH DRUG LOAD IMMEDIATE AND MODIFIED RELEASE ORAL DOSAGE FORMULATIONS AND PROCESSES FOR THEIR MANUFACTURE

摘要

This invention relates to high drug load granulation of (E)-.alpha.-[2-n-butyl-1-[(4-carboxyphenyl) methyl]-1H-imidazol-5-yl]methylene-2-thiophenepropionic acid in the anhydrous form, a process for itsproduction, compositions containing the compound andmethods of using the compound to block angiotensin II receptors and to treathypertension, congestive heart failure and renal failure.