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AND METHOD FOR PRODUCING Guggulsterones GUGGULSTEROLOV
AND METHOD FOR PRODUCING Guggulsterones GUGGULSTEROLOV
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机译:剂和古古甾酮的生产方法
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1.method u043fu043eu043bu0443u0447u0435u043du0438u00a0 4.17 (20) - z - u043fu0440u0435u0433u043du0430u0434u0438u0435u043d - 3.16 - dione below formula (iv), including oxidation u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 the following formula (ii) with respect to 4.17 (20) - e - u043fu0440u0435u0433u043du0430u0434u0438 yong - 3.16 - dione the following formula (iii) and processing of 4.17 (20) - e - u043fu0440u0435u0433u043du0430u0434u0438u0435u043d - 3.16 - dione the following formula (iii) in accordance with any of the reactions, u0432u044bu0431u0440u0430u043du043d s of the groupu0441u043eu0441u0442u043eu00a0u0449u0435u0439 of u0444u043eu0442u043eu0445u0438u043cu0438u0447u0435u0441u043au043eu0439 reaction u0442u0435u0440u043cu043eu0445u0438u043cu0438u0447u0435u0441u043au043eu0439 reactions and reactions carried out using acid catalyst;where does u0433u0438u0434u0440u043eu043au0441u0438u043bu044cu043du0443u044e group (he) or u043eu043au0441u043eu0433u0440u0443u043fu043fu0443 (= o), and u043fu0443u043du043au0442u0438u0440u043du0430u00a0 u043bu0438u043du0438u00a0 denotes the presence of a double u0441u0432u00a0u0437u0438 in position 4 or 5.;2. method for reaction 1, where u0444u043eu0442u043eu0445u0438u043cu0438u0447u0435u0441u043au0443u044e u043fu0440u043eu0432u043eu0434u00a0u0442 using u0444u043eu0442u043eu0441u0435u043du0441u0438u0431u0438u043bu0438u0437u0430u0442u043eu0440u0430, selected from the group u0441u043eu0441u0442u043eu00a0u0449u0435u0439 of u043cu0435u0442u0438u043bu0435u043du043eu0432u043eu0433u043e blue, u043cu0435u0442u0438u043bu0435u043du043eu0432u043eu0433u043e zelus u0435u043du043eu0433u043e and rose bengal.;3. method for reaction 1, where u0442u0435u0440u043cu043eu0445u0438u043cu0438u0447u0435u0441u043au0443u044e u043fu0440u043eu0432u043eu0434u00a0u0442 by u043du0430u0433u0440u0435u0432u0430u043du0438u00a0 u0440u0430u0441u0442u0432u043eu0440u0438u0442u0435u043bu00a0, benzene, toluene, xylene or u043cu0435u0437u0438u0442u0438u043bu0435u043du0430, with a fridge in the 80 200C... by the period of time of 1 to 48 hours.;4. method for 1, where an acid catalyst u00a0u0432u043bu00a0u0435u0442u0441u00a0 p - u0442u043eu043bu0443u043eu043bu0441u0443u043bu044cu0444u043eu043du043eu0432u0430u00a0 acid.;5. method u043fu043eu043bu0443u0447u0435u043du0438u00a0 u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formula (ii), as described in para.1, including the protection of u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formula (i a) 1.2 - u044du0442u0430u043du0434u0438u0442u0438u043eu043bu043eu043c receiving u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formula (i - a - 1), with the participation of the u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 wittig reaction formula (i - a - 1) p u043eu043bu0443u0447u0435u043du0438u0435u043c u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formula (i - a) 2, removing the protective group to obtain u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formula (i - a - 3) and the interaction of the u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 with selenium dioxide (SeO2);6. method u043fu043eu043bu0443u0447u0435u043du0438u00a0 u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formula (ii), as described in paragraph 1, including wittig reaction involving u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formulas (i) to obtain u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formula (i - 1) and mutually u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 synergies formula (i - 1) and selenium dioxide (SeO2);7. method u043fu043eu043bu0443u0447u0435u043du0438u00a0 u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formula (ii), as described in para.1, including wittig reaction involving u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formulas (i) to obtain u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formula (i - 1), the oxidation of the u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 u0445u043bu043eu0440u0445u0440u043eu043cu0430u0442u043eu043c u043fu0438u0440u0438u0434u0438u043du0438u00a0 (rs (c) to obtain u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formula (i, 2), the interaction of u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 in the presence of u043eu0441u043du043eu0432u0430u043du0438u00a0 receiving u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formulas (i to 3) and interaction of dan the main product with selenium dioxide;8. method u043fu043eu043bu0443u0447u0435u043du0438u00a0 u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formula (ii), as described in para.1, including the protection of u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formula (i -) 1.2 - u044du0442u0430u043du0434u0438u043eu043bu043eu043c in the presence of acid catalyst to obtain u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formula (i - 1), wittig reaction, involving the p u043eu043bu0443u0447u0435u043du043du043eu0433u043e u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 and u0433u0430u043bu043eu0433u0435u043du0438u0434u0430 u044du0442u0438u043bu0442u0440u0438u0444u0435u043du0438u043bu0444u043eu0441u0444u043eu043du0438u00a0 in the presence of strong u043eu0441u043du043eu0432u0430u043du0438u00a0 receiving u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formula (1 p-3)the removal of protection with the keto group u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formula (1 p-3) to obtain u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formula (i - a - 3) and the oxidation of the product of selenium dioxide;9. method u043fu043eu043bu0443u0447u0435u043du0438u00a0 u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formula (ii), as described in paragraph 1, including the interaction u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formula (i - d) with u0433u0438u0434u0440u0430u0437u0438u043du043eu043c, purity of more than 95% of u0441u043eu0441u0442u0430u0432u043bu00a0u0435u0442, in u0441u0443u0442u0441u0442u0432u0438u0438 u043eu0441u043du043eu0432u0430u043du0438u00a0 in 160C within 2 hours;10. method u043fu043eu043bu0443u0447u0435u043du0438u00a0 u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formula (ii), as described in para.1, including the restoration of u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formula (i, e) to obtain u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formula (i (- 1), the oxidation of the u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 using selective u043eu043au0438u0441u043bu00a0u044e with a reagent to obtain u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formula (i (2), a p - u0442u043eu043bu0443u043eu043bu0441u0443u043bu044cu0444u043eu043du0438u043bu044cu043du043eu0439 group or u043cu0435u0442u0430u043du0441u0443u043bu044cu0444u043eu043du0438u043bu044cu043du043eu0439 group in the compound of formula (i) (2) u043eu043bu0443u0447u0435u043du0438u0435u043c u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formula (i - e - 3)the interaction of the product with a base to obtain u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formula (i - e - 4) and interaction u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 formula (i - e - 4) with selenium dioxide
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