OXAZOLE DERIVATIVES SUBSTITUTED WITH CARBOXYLIC ACIDS AS PPAR-ALPHA AND PPAR-GAMMA ACTIVATORS IN DIABETES TREATMENT

摘要

FIELD: organic chemistry, medicine, endocrinology.;SUBSTANCE: invention relates to compounds of the formula (I): wherein R¹ means phenyl or naphthyl comprising the following substitutes: halogen atom, (lower)-alkyl, (lower)-alkoxy-group, trifluoromethyl (-CF₃), phenyl or heteroaryl representing aromatic 5-membered ring that comprises sulfur atom; each among R², R³, R⁴ and R⁶ and independently of one another means hydrogen atom, hydroxy-group, (lower)-alkenyl, halogen atom, (lower)-alkyl or (lower)-alkoxy-group wherein at least one radical among R², R³, R⁴ and R⁶ doesn't mean hydrogen atom, or R³ and R⁴ are bound and also bound with carbon atoms to which they are bound and form ring, and R³ and R⁴ mean in common -CH=CH-S-, -S-CH=CH-, -CH=CH-O-, -O-CH=CH-, -CH=CH-CH=CH-, -(CH₂)_3-5-, -O-(CH₂)_2-3 or -(CH₂)_2-3-O- wherein R² and R⁶ have above given values; R⁵ means (lower)-alkoxy-, (lower)-alkenyloxy-group, or ; R⁷ means hydrogen atom or (lower)-alkyl; R⁸ means (lower)-alkyl; R⁹ means hydrogen atom; R¹⁰ means phenyl or naphthyl that can be mono- or poly-substituted with -CF₃; n means 1, 2 or 3, and wherein the bond between C^a carbon atom and C^b carbon atom represents carbon-carbon single or double bond, and to their pharmaceutically acceptable salts and esters also. Indicated compounds can be used as therapeutically active substances in treatment and/or prophylaxis of diseases mediated by agonists of PPAR- and/or PPAR- receptors, for example, in treatment of diabetes.;EFFECT: valuable medicinal properties of compounds.;24 cl, 167 ex