METHOD OF PROGNOSING GENERALIZATION OF PROCESS IN CHILDREN AND ADOLESCENTS WITH OSTEAL SARCOMA

摘要

FIELD: oncology.;SUBSTANCE: method provides for early prognosis of generalization disease due to most wide biological action of thyroidal hormones regulating principal stages of metabolic processes in body and influencing proliferation velocity and functions of nervous and immune systems, whose status, in turn, greatly determines state of antitumor résistance. Method is characterized by performing complex antitumor treatment and biochemical investigation and in patients undergone complex treatment with complete clinical and laboratory remission level of free fraction of thyroidal hormone triiodothironine is determined in blood. When this level lies within a range of 4.0 to 5.2 pmol/ml, preservation of remission during 6 to 24 month is forecasted and, at the level 5.8 to 7.4 pmol/ml, generalization of malignant process within period of 1 to 3 months is expected.;EFFECT: increased reliability of prognosis.;1 tbl, 4 ex