COMPOSITION AND METHOD FOR PREPARING OPHTHALMIC HYDROCORTISONE OINTMENT

摘要

FIELD: chemical-pharmaceutical industry, pharmacy.;SUBSTANCE: invention relates to a method for preparing ophthalmic hydrocortisone ointment. Method involves mixing hydrocortisone acetate and a base prepared by melting Vaseline of sort "for ophthalmic ointments" and anhydrous lanolin at temperature 60-80°C at stirring, filtration through caprone fabric on funnel for hot filtration into thermostable capacity, sterilization in drying chamber at temperature 180-200°C for 1.5-2 h or in hermetic reactor by steam under pressure at temperature 120°C for 40-60 min, and preserving agents are added to the sterile melt at stirring. Ophthalmic ointment prepared by such method shows the improved adhesion properties and doesn't irritate the eye mucosa.;EFFECT: improved preparing method.;3 ex