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New phenyl ester compounds useful as antioxidants, for the reduction of skin aging, or for the prevention/treatment of inflammations, allergies and irritations of skin

机译:新型苯基酯化合物可用作抗氧化剂,用于减少皮肤老化或预防/治疗皮肤的炎症,过敏和刺激

摘要

Phenyl ester compounds (I) are new. Phenyl ester compounds of formula (I) are new. R1H, 1-30C alkyl, 1-30C hydroxyalkyl; X : CN, -C(=O)-R1 or -C(=O)-OR1; Y1H or Ar, where Ar is benzene compound of formula (a); and R2-R6H, OH, 1-20C alkoxy, 1-20C alkyl, 3-20C alkenyl, 1-20C hydroxyalkyl (where the hydroxy group is bound to a primary or secondary carbon atom of the chain and the alkyl chain is interrupted by O), or 1-20C hydroxyalkoxy (where the hydroxy group is bounded at primary or secondary carbon atoms of the chain and the alkyl chain is interrupted by O), where one of R2-R6 is 1-20C alkoxy or 2-20C alkylenoxy-spacer, which is bound over Si-atom at oligo- or polysiloxane chain. Independent claims are included for: (1) a composition comprising (I) and at least one cosmetic or dermatological composition or household product suitable carrier; and (2) the preparation of (I). [Image] ACTIVITY : Dermatological; Antiinflammatory; Antiallergic; Cytostatic. MECHANISM OF ACTION : None given.
机译:苯基酯化合物(I)是新的。式(I)的苯基酯化合物是新的。 R1> H,1-30C烷基,1-30C羟烷基; X:CN,-C(= O)-R1>或-C(= O)-OR1>; Y 1> H或Ar,其中Ar是式(a)的苯化合物; R2> -R6> H,OH,1-20C烷氧基,1-20C烷基,3-20C烯基,1-20C羟烷基(其中羟基与链和烷基链的伯或仲碳原子键合)或1-20C羟基烷氧基(其中羟基键合在链的伯或仲碳原子上,而烷基链被O中断),其中R2> -R6>之一是1-20C烷氧基或2-20C亚烷基氧间隔基,它在低聚或聚硅氧烷链上的Si原子上结合。包括以下独立权利要求:(1)一种组合物,其包含(I)和至少一种化妆品或皮肤病学组合物或家用产品合适的载体; (2)制备(I)。 [图像]活动:皮肤病;消炎(药;抗过敏;止细胞的。作用机理:未给出。

著录项

  • 公开/公告号DE102005018184A1

    专利类型

  • 公开/公告日2006-10-26

    原文格式PDF

  • 申请/专利权人 MERCK PATENT GMBH;

    申请/专利号DE20051018184

  • 发明设计人 RUDOLPH THOMAS;BUCHHOLZ HERWIG;

    申请日2005-04-19

  • 分类号C07C69/73;C07C59/52;C07B35/02;A61K8/37;A61K8/36;A61K8/39;A61K8/362;A61K8/89;A61Q17;A61Q19;A61K31/216;A61P17/18;

  • 国家 DE

  • 入库时间 2022-08-21 21:20:16

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