PGC-1amp;alpha; EXPRESSION PROMOTER, PGC-1amp;alpha; EXPRESSION INHIBITOR AND METHOD FOR USING THEM

摘要

PROBLEM TO BE SOLVED: To obtain a PGC-1α (Peroxisome proliferator activated receptor γ coactivator 1α) expression promoter through a selective β₂ receptor and a PGC-1α expression inhibitor through a β receptor and to provide a method for using them.;SOLUTION: The expression of PGC-1α mRNA in skeletal muscle is promoted by administration of a medicine (clenbuterol) stimulating a β₂ receptor. The expression increase of PGC-1α mRNA in skeletal muscle by locomotor stimulation is inhibited by administration of a medicine (propranolol) blocking a β receptor. In this manner, a medicine containing a β₂ stimulator promotes PGC-1α expression and increases the number of mitochondria in skeletal muscle. Also, a medicine containing a β blocker controls the expression increase of PGC-1α and increases the number of mitochondria in skeletal muscle.;COPYRIGHT: (C)2007,JPO&INPIT