LYMPHOCYTE ACTIVATION ANTIGEN HB15: MEMBER OF IMMUNOGLOBULIN SUPERFAMILY

摘要

PPROBLEM TO BE SOLVED: To provide a novel cell-surface glycoprotein, termed HB15, expressed by activated lymphocytes. PSOLUTION: Lymphocyte activation antigen HB15, and a human cDNA encoding HB15 and gene sequences thereof, are disclosed. HB15 is not expressed at detectable levels by circulating leukocytes but has a unique pattern of expression among tissues. HB15 is uniquely expressed by Langerhans cells within the skin and other subpopulations of dendritic cells. Also disclosed are antibodies reactive with HB15 and methods of using anti-HB15 antibodies, or other antagonists to HB15 function, to treat an immunological disorder, disease or syndrome. PCOPYRIGHT: (C)2007,JPO&INPIT