N - 3 - (3-cyanopyrazolo 1,5-a pyrimidin-7-yl) - phenyl - N-ethyl acetamide synthesis method

摘要

The present invention relates to N - [3 - (3-cyanopyrazolo [1,5-a] pyrimidine-7-yl) - phenyl] - n-ethyl-acetamide which contains an impurity of less than 0.2%, which is suitable for therapeutic applications. Further, the present invention relates to a method of synthesizing compounds which can be applied to the treatment of formula (IV) containing impurities of less than 0.2%, which is a novel intermediate n - {3 - [3 - (dimethylamino) - 1-oxo-2-prope of formula (II)] The reaction is catalyzed by an acid free medium. The present invention also relates to a novel n - {3 - [3 - (dimethylamino) - 1-oxo-2-propenyl] phenyl fur-n-ethylacetamide hydrochloride of formula (II). In addition, the present invention is a new N - {3 - [3 -] (dimech) of formula (II) having a purity greater than 99.5%The present invention also relates to a method of synthesizing an amino - 1-oxo-2-propenyl phenyl furan N-ethyl acetamide hydrochloride. The present invention is also a new isolated impurity formed at a yield of 0.07% upon the synthesis of the compound of formula (IV): n - {3 - (3-cyanopyrazolo (1,5-a) pyrimidine] - 6-il-3 - (3-n-ethyl-a), which is a new isolated impurity formed at a yield of It is also related to phenyl-n-ethyl-acetamide.