Prognosis of kidney cancer and MN / CAIX / CA9

摘要

Disclosed herein is a prognostic methods related to kidney clear cell carcinoma, particularly renal cell carcinoma affecting the vertebrate. Comprising the step of quantifying the extent and level of the steps and / or detecting the presence of MN / CA9 gene expression product in a sample derived from patients suffering from, prognostic exemplary method, cells less than 50% where are considered the patient as having a poorer prognosis when to express MN / CA9 gene was found. As MN / CA9 gene expression product is useful in preload after diagnostic methods, MN protein, MN nucleic acid is included and MN / or polypeptides. The method is useful as an aid to the selection of treatment for renal cell carcinoma patients in a form combined with information on grade and tumor stage or conventional / or alone. For example, the method of the present invention can be used to identify patients most likely to respond to Ashubanto immunotherapy such as MN / CA IX / CA9 targeted therapy, particularly patient or requiring more aggressive therapy regimens.